Biosketch: Prof. Tapan K. Chaudhuri


Dr. Tapan K. Chaudhuri received his Bachelors and Masters degree in chemistry from the University of Calcutta. He has carried out his Ph.D. degree from Bose Institute, Calcutta in 1996. Dr. Chaudhuri’s Ph.D. research involves folding, physico-chemical characterization and conformational studies with protease inhibitors. Dr. Chaudhuri was a Japan Society for the Promotion of Science (JSPS) fellow in the Laboratory of Prof. K. Kuwajima, Department of Physics, University of Tokyo, Japan during 1996-1998. During his tenure as JSPS fellow in Japan, Dr. Chaudhuri has worked with the mechanism of protein folding and unfolding of genetically Engineered proteins using fast kinetic methods like stopped-flow CD and Fluorescence and has published some of his observations in Journal of Molecular Biology and Biochemistry . In his subsequent visits to Japan, Dr. Chaudhuri got involved in the structural studies on Chaperonin GroEL and GroES, and some of the observations were published in the Protein Science and Journal of Molecular Biology.

Dr. Tapan K. Chaudhuri was also a Howard Hughes Medical Institute Associate (HHMI) in the laboratory of Prof. Arthur L. Horwich, in the Department of Genetics, Yale University Medical School, USA during 1998-2001. As a HHMI fellow Dr. Chaudhuri has worked with in vivo and in vitro chaperone mediated protein folding issues. His major contribution in the field involves the elucidation of mechanism of GroEL-GroES mediated folding of larger recombinant substrate proteins in Escherichia coli system. The observations were published in Cell and EMBO journal, PNAS (USA) etc. Dr. Tapan K. Chaudhuri has started his career as an Assistant Professor in the Department of Biochemical Engineering and Biotechnology, IIT Delhi in September 2002, and he is holding the Professor position in the newly established School of Biological Sciences, IIT Delhi since December 2012. His present research interests include Chaperone mediated folding studies of large and small homologous and heterologous substrates in Escherichia coli. He is also involved in developing suitable methods for the production of correctly folded recombinant proteins in cells using the assistance of molecular chaperones GroEL and GroES. Dr. Chaudhuri is also involved in the projects related to the protein Engineering approach for the elucidation of Function of different parts of the protein molecules.

Research Interests

  1. Chaperone assisted protein folding.
  2. Equilibrium, Kinetics and Thermodynamics of protein folding reactions.
  3. Molecular Biophysics, protein conformational properties and structure-Function relationship of recombinant proteins

experience

Professor, Kusuma School of Biological Sciences, IIT Delhi

July 2018- PresentContinuing

Professor & Head of School, Kusuma School of Biological Sciences, IIT Delhi

June 2014-July 2018

Professor, Kusuma School of Biological Sciences, IIT Delhi

December 2012- May 2014

Associate Professor, Kusuma School of Biological Sciences, IIT Delhi

Aug-2008 to Dec-2012

Visiting Professor, Kansas University Medical School, USA.

Feb-2012 to july-2012

Assistant Professor, Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi.

Sep-2002 to Aug-2008

Visiting Scientist, Institute of Molecular Science, Japan.

May-2010 to july-2010

Visiting Professor, Yale University, USA.

June-2009 to July-2009

Invited Scientist, Institute of Molecular Science, Japan.

Aug-2007 to July-2008

Visiting Professor, Yale University, USA.

June-2006 to July-2006

Visiting Professor, University of Konstanz, Germany.

JJune-2005 to July-2005

Visiting Professor, Yale University, USA.

June-2004 to July-2004

education

Post Doctoral Research Associate, Department of Biology, University of Utah, Salt lake city , Utah, USA.

2001-2002

Post Doctoral Research Associate, Howard Hughes Medical Institute Associate (HHMI), A. L. Horwich Lab, Yale University, USA.

2001

JSPS: Post Doctoral Fellow, Lab of Prof. K. Kuwajima, University of Tokyo, Japan.

1996-1998

Ph.D.(Chemistry), Bose Institute Calcutta, Degree awarded by Calcutta University, India.

1995
.

M.Sc.(Chemistry), Specialization in Organic Chemistry, Calcutta University, India.

1989

B.Sc.(Chemistry Honours), Calcutta University, India.

1985

education

2018

Indian Patent application No. 201811016096/TEMP/E-1/16930/2018-DEL; filed on Feb 02, 2018.

Tapan K Chaudhuri and Sarita Puri, “Improvement of stability and functioning of GroEL protein and implementation thereof.”.

2018

Indian Patent application No. 201811029173; filed on August 02, 2018.

Tapan K Chaudhuri and Vishal Srivastava, “Process for Producing Mature Serratiopeptidase”.

2017

US Patent application No. 15588379; filed on May 05, 2017.

Tapan K Chaudhuri and Ashima Sharma, “Process for enhanced production of recombinant human serum albumin in Escherichia coli through chaperone assistance".

2016

Indian patent application No. 201611045154; filed on December 30, 2016.

Tapan K Chaudhuri and Ashima Sharma, “Process for enhanced production of recombinant human serum albumin in Escherichia coli through chaperone assistance".

2016

Indian patent application No. 201611027096; filed on August 08, 2016.

Tapan K Chaudhuri and Ashima Sharma, “Process for production, and isolation of recombinant human serum albumin in Escherichia coli”.

2015

Indian patent application No. 2437/DEL/2015, filed on August 7, 2015.

Tapan K. Chaudhuri and Gayathri Ravitchandirane, “Process for Expression of Biologically Active Recombinant Proteins in Escherichia coli".

2014

Indian patent application No. 669/DEL/2014. (CBR No. 3261),Docket no. 4520; filed on March 10, 2014.

Tapan K. Chaudhuri and Megha Goyal, “A process for chaperone assisted folding of multiple recombinant proteins in simultaneously in Escherichia coli”.

2012

Indian patent application No. 1018/DEL/2012; filed on April 2, 2012

Tapan K Chaudhuri and Vinay Dahiya, "Process of refolding of recombinant protein".