- Chaperone assisted protein folding.
- Equilibrium, Kinetics and Thermodynamics of protein folding reactions.
- Molecular Biophysics, protein conformational properties and structure-Function relationship of recombinant proteins
Dr. Tapan K. Chaudhuri received his Bachelors and Masters degree in chemistry from the University of Calcutta. He has carried out his Ph.D. degree from Bose Institute, Calcutta in 1996. Dr. Chaudhuri’s Ph.D. research involves folding, physico-chemical characterization and conformational studies with protease inhibitors. Dr. Chaudhuri was a Japan Society for the Promotion of Science (JSPS) fellow in the Laboratory of Prof. K. Kuwajima, Department of Physics, University of Tokyo, Japan during 1996-1998. During his tenure as JSPS fellow in Japan, Dr. Chaudhuri has worked with the mechanism of protein folding and unfolding of genetically Engineered proteins using fast kinetic methods like stopped-flow CD and Fluorescence and has published some of his observations in Journal of Molecular Biology and Biochemistry . In his subsequent visits to Japan, Dr. Chaudhuri got involved in the structural studies on Chaperonin GroEL and GroES, and some of the observations were published in the Protein Science and Journal of Molecular Biology.
Dr. Tapan K. Chaudhuri was also a Howard Hughes Medical Institute Associate (HHMI) in the laboratory of Prof. Arthur L. Horwich, in the Department of Genetics, Yale University Medical School, USA during 1998-2001. As a HHMI fellow Dr. Chaudhuri has worked with in vivo and in vitro chaperone mediated protein folding issues. His major contribution in the field involves the elucidation of mechanism of GroEL-GroES mediated folding of larger recombinant substrate proteins in Escherichia coli system. The observations were published in Cell and EMBO journal, PNAS (USA) etc. Dr. Tapan K. Chaudhuri has started his career as an Assistant Professor in the Department of Biochemical Engineering and Biotechnology, IIT Delhi in September 2002, and he is holding the Professor position in the newly established School of Biological Sciences, IIT Delhi since December 2012. His present research interests include Chaperone mediated folding studies of large and small homologous and heterologous substrates in Escherichia coli. He is also involved in developing suitable methods for the production of correctly folded recombinant proteins in cells using the assistance of molecular chaperones GroEL and GroES. Dr. Chaudhuri is also involved in the projects related to the protein Engineering approach for the elucidation of Function of different parts of the protein molecules.