Funded research projects completed / continuing:

Our Lab's research interest include Chaperone mediated folding studies of large and small homologous and heterologous substrates in Escherichia coli. We are also involved in developing suitable methods for the production of correctly folded recombinant proteins in cells using the assistance of molecular chaperones GroEL and GroES, utilizing protein Engineering approaches for the elucidation of function of different parts of the protein molecules to understand the role and to develop functionally efficient counterparts. Our lab is involved in variety of projects supported by different funding bodies of governemnt of India.



A mechanistic approach for understanding acid resistance by Enterohemorrhagic Escherichia coli in mammalian stomach.

Funding Agency:
Department of Science and Technology (DST), Govt. of India, under NPDF program.
Role:
Principle investigator
Value:
19,20,000 Indian rupee
Tenure:
3 years (April 2017-April 2020)
Status:
Ongoing





Production of a crucial therapeutic protein for Trauma and Accident care in Escherichia coli system.

Funding Agency:
IMPRINT (Proposal No. 4192 (Health Care domain), Govt. of India.
Role:
Principle investigator (Along with Co-PIs-Prof. Amit K. Dinda, AIIMS; Prof. K.J. Mukherjee, JNU New Delhi.)
Value:
60,00,000 Indian rupee
Tenure:
3 years (May 2017-May 2020)
Status:
Ongoing





Satellite project-I: Development of strategies for recombinant production and functional expression of therapeutically important proteins in microbial systems.

Funding Agency:
Department of Biotechnology (DBT) Centre of Excellence for Biopharmaceutical Technology.
Role:
Principle investigator.
Value:
37,54,000 Indian rupee
Tenure:
3 years (Nov 2015-Nov 2018)
Status:
Ongoing





Characterisation of refolding intermediates of multi-domain protein malate synthase G using mass spectroscopic method.

Funding Agency:
Department of Science and Technology (DST) Government of India-sanctioned to Dr. Shikha Taneja as woman scientist(DST No. SR/WOS-A/LS-511/2013)(G).
Role:
Mentor and Principle investigator.
Value:
19,10,000 Indian rupee
Tenure:
3 years (Sep 2014-Sep 2017)
Status:
Completed





GroEL-GroES assisted folding of multiple proteins in vivo and in vitro.

Funding Agency:
Department of Science and Technology (DST) Government of India-RP 02767,SR/SO/BB-0040/2012.
Role:
Principle investigator.
Value:
28,99,600 Indian rupee
Tenure:
3 years (Aug 2013-Aug 2016)
Status:
Completed





Identification of chaperone binding region in the aggregation prone protein Maltodextrin glucosidase, which undergoes GroEL/GroES assisted folding.

Funding Agency:
Council of Scientific & Industrial Research (CSIR) Government of India-RP 02777, 37(1565)/12/EMR-II.
Role:
Principle investigator.
Value:
21,42,600 Indian rupee
Tenure:
3 years (Aug 2013-Aug 2016)
Status:
Completed